Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical
roles in normal development, tissue homeostasis and immunity, and its disturbed regulation …

Although the BCL-2 family constitutes a crucial checkpoint in apoptosis, the intricate
interplay between these family members remains elusive. Here, we demonstrate that BIM …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

The cell intrinsic factors that determine whether a neuron regenerates or undergoes
apoptosis in response to axonal injury are not well defined. Here we show that the mixed …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

Programmed cell death—also known as apoptosis—has a crucial role in the immune system
of mammals and other animals. It removes useless cells and potentially dangerous cells …

The execution of apoptosis is critical for proper development of the nervous system.
However, it is equally important that neurons strictly inhibit apoptosis after development to …