Cold shock proteins: from cellular mechanisms to pathophysiology and disease
JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …
presence of one or more cold shock domains. In humans, the best characterized members of …
Challenges in paragangliomas and pheochromocytomas: from histology to molecular immunohistochemistry
CC Juhlin - Endocrine pathology, 2021 - Springer
Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine
tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although …
tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although …
Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
The assembly of cortical circuits involves the generation and migration of interneurons from
the ventral to the dorsal forebrain,–, which has been challenging to study at inaccessible …
the ventral to the dorsal forebrain,–, which has been challenging to study at inaccessible …
A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia
A Laddach, SH Chng, R Lasrado, F Progatzky… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …
underpinning the neurogenic potential of adult glia are not known. Using single cell …
DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis
A Thiruvalluvan, EP de Mattos, JF Brunsting, R Bakels… - Molecular cell, 2020 - cell.com
CAG-repeat expansions in at least eight different genes cause neurodegeneration. The
length of the extended polyglutamine stretches in the corresponding proteins is …
length of the extended polyglutamine stretches in the corresponding proteins is …
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
CB Driscoll, MR Schuelke, T Kottke… - Nature …, 2020 - nature.com
APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been
implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity …
implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity …
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell
fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a …
fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a …
FABP7 upregulation induces a neurotoxic phenotype in astrocytes
KM Killoy, BA Harlan, M Pehar, MR Vargas - Glia, 2020 - Wiley Online Library
Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy
homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their …
homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their …
The role of CSDE1 in translational reprogramming and human diseases
AX Guo, JJ Cui, LY Wang, JY Yin - Cell Communication and Signaling, 2020 - Springer
CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming,
which determines the fate of a number of RNAs during biological processes. Interestingly …
which determines the fate of a number of RNAs during biological processes. Interestingly …
RNA-binding proteins regulate post-transcriptional responses to TGF-β to coordinate function and mesenchymal activation of murine endothelial cells
BACKGROUND: Endothelial cells (ECs) are primed to respond to various signaling cues.
For example, TGF (transforming growth factor)-β has major effects on EC function and …
For example, TGF (transforming growth factor)-β has major effects on EC function and …