Cold shock proteins: from cellular mechanisms to pathophysiology and disease

JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

Challenges in paragangliomas and pheochromocytomas: from histology to molecular immunohistochemistry

CC Juhlin - Endocrine pathology, 2021 - Springer
Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine
tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although …

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment

X Meng, D Yao, K Imaizumi, X Chen, KW Kelley, N Reis… - Nature, 2023 - nature.com
The assembly of cortical circuits involves the generation and migration of interneurons from
the ventral to the dorsal forebrain,–, which has been challenging to study at inaccessible …

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

A Laddach, SH Chng, R Lasrado, F Progatzky… - Nature …, 2023 - nature.com
Glial cells have been proposed as a source of neural progenitors, but the mechanisms
underpinning the neurogenic potential of adult glia are not known. Using single cell …

DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis

A Thiruvalluvan, EP de Mattos, JF Brunsting, R Bakels… - Molecular cell, 2020 - cell.com
CAG-repeat expansions in at least eight different genes cause neurodegeneration. The
length of the extended polyglutamine stretches in the corresponding proteins is …

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

CB Driscoll, MR Schuelke, T Kottke… - Nature …, 2020 - nature.com
APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been
implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity …

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

DTT Nguyen, Y Lu, EL Chu, X Yang, SM Park… - Nature …, 2020 - nature.com
The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell
fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a …

FABP7 upregulation induces a neurotoxic phenotype in astrocytes

KM Killoy, BA Harlan, M Pehar, MR Vargas - Glia, 2020 - Wiley Online Library
Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy
homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their …

The role of CSDE1 in translational reprogramming and human diseases

AX Guo, JJ Cui, LY Wang, JY Yin - Cell Communication and Signaling, 2020 - Springer
CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming,
which determines the fate of a number of RNAs during biological processes. Interestingly …

RNA-binding proteins regulate post-transcriptional responses to TGF-β to coordinate function and mesenchymal activation of murine endothelial cells

R Wardman, M Keles, I Pachkiv… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Endothelial cells (ECs) are primed to respond to various signaling cues.
For example, TGF (transforming growth factor)-β has major effects on EC function and …