Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
[HTML][HTML] Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes
L Cyganek, M Tiburcy, K Sekeres, K Gerstenberg… - JCI insight, 2018 - ncbi.nlm.nih.gov
Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …
Animal models of atrial fibrillation
D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
[HTML][HTML] Calcium in the pathophysiology of atrial fibrillation and heart failure
NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …
Translational challenges in atrial fibrillation
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …
with substantial morbidity and mortality. Current treatment options for AF have significant …
Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation
Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …