Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is
involved in complex immunomodulatory and antitumoral mechanisms and has been …

Detecting recent selected 'genomic footprints' applies directly to the discovery of disease
genes and in the imputation of the formative events that molded modern population genetic …

Hereditary congenital facial paresis type 1 (HCFP1) is an autosomal dominant disorder of
absent or limited facial movement that maps to chromosome 3q21-q22 and is hypothesized …

INTRODUCTION Cellular senescence is a program of arrested proliferation and altered
gene expression triggered by many stresses. Although it is a potent tumor-suppressive …

Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous
epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor …

Hair follicle (HF) regeneration begins when communication between quiescent epithelial
stem cells (SCs) and underlying mesenchymal dermal papillae (DP) generates sufficient …

Fibroblasts, the most abundant structural cells, exert homeostatic functions but also drive
disease pathogenesis. Single-cell technologies have illuminated the shared characteristics …

TGF-β is known to influence tumour progression. Here we report an additional role of Smad3
in the tumour microenvironment regulating cancer progression. Deletion or inhibition of …

Embryonic stem cell (ESC) pluripotency is dependent on an intrinsic gene regulatory
network centered on Oct4. Propagation of the pluripotent state is stimulated by the cytokine …

Transforming growth factor β (TGF-β)/Smad3 signaling plays a role in tissue fibrosis. We
report here that Erbb4-IR is a novel long non-coding RNA (lncRNA) responsible for TGF …