Advantages and limitations of animal schizophrenia models
M Białoń, A Wąsik - International Journal of Molecular Sciences, 2022 - mdpi.com
Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …
schizophrenia are essential to gain a better understanding of the disease etiopathology and …
Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases
M Wang, Y Xie, D Qin - Brain Research Bulletin, 2021 - Elsevier
Brain-derived neurotrophic factor (BDNF) is involved in pathophysiological mechanisms in
neuropsychiatric diseases, including depression, anxiety, and schizophrenia (SZ), as well as …
neuropsychiatric diseases, including depression, anxiety, and schizophrenia (SZ), as well as …
Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …
JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …
Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
complex epigenetic-mediated neurobiological changes causing behavioural deficits …
[HTML][HTML] Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice
B Ben-Azu, EE Nwoke, AO Aderibigbe… - Biomedicine & …, 2019 - Elsevier
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to
prevent and suppress several human diseases, and are important sources of therapeutic …
prevent and suppress several human diseases, and are important sources of therapeutic …
Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone‐induced mice model of Parkinson's disease: Role of executioner …
Asymptomatic and early clinical stages of Parkinson's disease (PD) have been linked with
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …
Lead acetate induces hippocampal pyramidal neuron degeneration in mice via up-regulation of executioner caspase-3, oxido-inflammatory stress expression and …
Purpose It has been hypothesized that compounds with strong anti-oxidant activity might
mitigate lead-induced neurotoxicity that resulted to neuronal degeneration. Ginkgo biloba …
mitigate lead-induced neurotoxicity that resulted to neuronal degeneration. Ginkgo biloba …
Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …
Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and …
CC Onyekweli, B Ben-Azu, OM Oyovwi… - Food and Chemical …, 2024 - Elsevier
This study investigated whether epigallocatechin-gallate (EGCG) could counteract the
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …