Advantages and limitations of animal schizophrenia models

M Białoń, A Wąsik - International Journal of Molecular Sciences, 2022 - mdpi.com
Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases

M Wang, Y Xie, D Qin - Brain Research Bulletin, 2021 - Elsevier
Brain-derived neurotrophic factor (BDNF) is involved in pathophysiological mechanisms in
neuropsychiatric diseases, including depression, anxiety, and schizophrenia (SZ), as well as …

Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …

B Ben-Azu, OG Adebayo, EG Moke… - Journal of Psychiatric …, 2023 - Elsevier
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …

Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of …

JOT Emudainohwo, B Ben-Azu, OG Adebayo… - Journal of Molecular …, 2023 - Springer
Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Reversal and preventive pleiotropic mechanisms involved in the antipsychotic-like effect of taurine, an essential β-amino acid in ketamine-induced experimental …

B Ben-Azu, CI Uruaka, AM Ajayi, TA Jarikre… - Neurochemical …, 2023 - Springer
Schizophrenia is a life disabling, multisystem neuropsychiatric disease mostly derived from
complex epigenetic-mediated neurobiological changes causing behavioural deficits …

[HTML][HTML] Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice

B Ben-Azu, EE Nwoke, AO Aderibigbe… - Biomedicine & …, 2019 - Elsevier
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to
prevent and suppress several human diseases, and are important sources of therapeutic …

Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone‐induced mice model of Parkinson's disease: Role of executioner …

OG Adebayo, JN Asiwe, B Ben‐Azu… - Journal of Food …, 2022 - Wiley Online Library
Asymptomatic and early clinical stages of Parkinson's disease (PD) have been linked with
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …

Lead acetate induces hippocampal pyramidal neuron degeneration in mice via up-regulation of executioner caspase-3, oxido-inflammatory stress expression and …

B Ben-Azu, OG Adebayo, I Wopara, W Aduema… - Journal of Trace …, 2022 - Elsevier
Purpose It has been hypothesized that compounds with strong anti-oxidant activity might
mitigate lead-induced neurotoxicity that resulted to neuronal degeneration. Ginkgo biloba …

Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin

AEO Eneni, B Ben-Azu, AM Ajayi… - Journal of Molecular …, 2023 - Springer
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …

Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and …

CC Onyekweli, B Ben-Azu, OM Oyovwi… - Food and Chemical …, 2024 - Elsevier
This study investigated whether epigallocatechin-gallate (EGCG) could counteract the
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …