Mechanisms and consequences of macromolecular phase separation
Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …
A decade and a half of protein intrinsic disorder: biology still waits for physics
VN Uversky - Protein Science, 2013 - Wiley Online Library
The abundant existence of proteins and regions that possess specific functions without
being uniquely folded into unique 3D structures has become accepted by a significant …
being uniquely folded into unique 3D structures has become accepted by a significant …
[HTML][HTML] Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana
The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and
development. The auxin response factor (ARF) transcription factor family regulates auxin …
development. The auxin response factor (ARF) transcription factor family regulates auxin …
Intrinsically disordered proteins from A to Z
VN Uversky - The international journal of biochemistry & cell biology, 2011 - Elsevier
The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
Unmasking the roles of N-and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
Huntington disease is caused by mutational expansion of the CAG trinucleotide within exon
1 of the huntingtin (Htt) gene. Exon 1 spanning N-terminal fragments (NTFs) of the Htt …
1 of the huntingtin (Htt) gene. Exon 1 spanning N-terminal fragments (NTFs) of the Htt …
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins
F Fiumara, L Fioriti, ER Kandel, WA Hendrickson - Cell, 2010 - cell.com
The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of
polyQ-expanded proteins involve complex aggregation-prone structural transitions …
polyQ-expanded proteins involve complex aggregation-prone structural transitions …
Connecting coil-to-globule transitions to full phase diagrams for intrinsically disordered proteins
Phase separation is thought to underlie spatial and temporal organization that is required for
controlling biochemical reactions in cells. Multivalence of interaction motifs, also known as …
controlling biochemical reactions in cells. Multivalence of interaction motifs, also known as …
Proteins containing expanded polyglutamine tracts and neurodegenerative disease
A Adegbuyiro, F Sedighi, AW Pilkington IV… - Biochemistry, 2017 - ACS Publications
Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …
Collapse transitions of proteins and the interplay among backbone, sidechain, and solvent interactions
AS Holehouse, RV Pappu - Annual Review of biophysics, 2018 - annualreviews.org
Proteins can collapse into compact globules or form expanded, solvent-accessible, coil-like
conformations. Additionally, they can fold into well-defined three-dimensional structures or …
conformations. Additionally, they can fold into well-defined three-dimensional structures or …
Kinase inhibitors modulate huntingtin cell localization and toxicity
Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for
modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's …
modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's …