Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …
Advances in histone demethylase KDM4 as cancer therapeutic targets
DH Lee, GW Kim, YH Jeon, J Yoo, SW Lee… - The FASEB …, 2020 - Wiley Online Library
Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …
A community effort to assess and improve drug sensitivity prediction algorithms
Predicting the best treatment strategy from genomic information is a core goal of precision
medicine. Here we focus on predicting drug response based on a cohort of genomic …
medicine. Here we focus on predicting drug response based on a cohort of genomic …
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Breast cancer is the most frequent cancer in women and consists of heterogeneous types of
tumours that are classified into different histological and molecular subtypes,. PIK3CA and …
tumours that are classified into different histological and molecular subtypes,. PIK3CA and …
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
Histone methyltransferases and demethylases reversibly modulate histone lysine
methylation, which is considered a key epigenetic mark associated with gene regulation …
methylation, which is considered a key epigenetic mark associated with gene regulation …
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that
play key roles in breast cancer biology. We hypothesized that interaction of HIF-1 with …
play key roles in breast cancer biology. We hypothesized that interaction of HIF-1 with …
DNA methylation readers and cancer: mechanistic and therapeutic applications
N Mahmood, SA Rabbani - Frontiers in oncology, 2019 - frontiersin.org
DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …
causes transcriptional activation or repression of genes in a context-dependent manner. In …
[HTML][HTML] Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential
RM Labbé, A Holowatyj, ZQ Yang - American journal of …, 2014 - ncbi.nlm.nih.gov
KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
KDM4C and ATF4 cooperate in transcriptional control of amino acid metabolism
The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through
gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not …
gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not …
[HTML][HTML] Genomic amplification of 9p24. 1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer
MT Barrett, KS Anderson, E Lenkiewicz, M Andreozzi… - Oncotarget, 2015 - ncbi.nlm.nih.gov
We used DNA content flow cytometry followed by oligonucleotide array based comparative
genomic hybridization to survey the genomes of 326 tumors, including 41 untreated …
genomic hybridization to survey the genomes of 326 tumors, including 41 untreated …