C1 domains are small zinc-binding structural units of approximately 50 amino acid residues,
originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. Although …

Abstract Alzheimer's disease (AD), the most common cause of dementia, is an irreversible
and progressive neurodegenerative disorder. It affects predominantly brain areas that are …

Cells latently infected with human immunodeficiency virus type 1 (HIV-1) prevent people
living with HIV-1 from obtaining a cure to the infectious disease. Latency reversing agents …

Protein kinase C (PKC) is a widely studied molecular target for the treatment of cancer and
other diseases. We have approached the issue of modifying PKC function by targeting the …

Cancer is one of the leading causes of death globally, accounting for an estimated 8 million
deaths each year. As a result, there have been urgent unmet medical needs to discover …

Despite our extensive knowledge on the biology of protein kinase C (PKC) and its
involvement in disease, limited success has been attained in the generation of PKC isozyme …

Engineered overexpression of protein kinase Cα (PKCα) was previously shown to endow
nonmotile MCF-10A human breast cells with aggressive motility. A traceable mutant of PKCα …

Diacylglycerol (DAG) is a key lipid second messenger downstream of cellular receptors that
binds to the C1 domain in many regulatory proteins. Protein kinase C (PKC) isoforms …

Munc13-1 is a key protein necessary for vesicle fusion and neurotransmitter release in the
brain. Diacylglycerol (DAG)/phorbol ester binds to its C1 domain in the plasma membrane …

The second messenger diacylglycerol (DAG) plays a central role in the signal transduction
of G-protein coupled receptors and receptor tyrosine kinases by binding to C1 domain of …