Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key
model system for neural stem cell biology and have provided key insights into the …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

The ADP ribosyl transferase [poly (ADP-ribose) polymerase] ARTD3 (PARP3) is a newly
characterized member of the ARTD (PARP) family that catalyzes the reaction of ADP …

Like phosphorylation, the addition of O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a
ubiquitous, reversible process that modifies serine and threonine residues on nuclear and …

Dysregulation of O‐GlcNAc modification catalyzed by O‐GlcNAc transferase (OGT) and O‐
GlcNAcase (OGA) contributes to the etiology of chronic diseases of aging, including cancer …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

Abstract Systems-level assessments of protein-protein interaction (PPI) network dysfunctions
are currently out-of-reach because approaches enabling proteome-wide identification …

Orientation of the cell division axis is essential for the correct development and maintenance
of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of …

Cell cycle errors can lead to mutations, chromosomal instability, or death; thus, the precise
control of cell cycle progression is essential for viability. The nutrient-sensing post …