In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …

T cell priming to exogenous antigens reflects regulated antigen processing in dendritic cells,
subsequent homing to lymph nodes, sustained interactions between T cells and antigen …

llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and
protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and …

Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …

In both the MHC class II and class I pathways of antigen presentation, accessory molecules
influence formation of MHC–peptide complexes. In the MHC class II pathway, DM functions …

Proteins of the class II major histocompatibility complex (MHC) bind antigenic peptides that
are subsequently presented to T cells. Previous studies have shown that most of the …

The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …

The peptide spanning residues 48–62 of hen egg white lysozyme presented by IA k
molecules gives rise to two T cell populations, types A and B, that recognize distinct …