Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …

CD4+ helper T cells contribute important functions to the immune response during pathogen
infection and tumor formation by recognizing antigenic peptides presented by class II major …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …

All the time, echinococcosis is a global zoonotic disease which seriously endangers public
health all over the world. In order to speed up the development process of anti …

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major
histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to …

Highlights•Immunodominant epitope processing and selection requires DM, MHC II, and
cathepsins.•Immunodominance is determined by epitope abundance.•Antigens from …

The selection of peptides for presentation at the surface of most nucleated cells by major
histocompatibility complex class I molecules (MHC I) is crucial to the immune response in …