Encapsulation and immune protection for type 1 diabetes cell therapy
S Kioulaphides, AJ García - Advanced Drug Delivery Reviews, 2024 - Elsevier
Abstract Type 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-
cells in the pancreas. Exogenous insulin injections are the current therapy but are user …
cells in the pancreas. Exogenous insulin injections are the current therapy but are user …
[HTML][HTML] Vascular and immune interactions in islets transplantation and 3D islet models
A Migliorini, MC Nostro - Current Opinion in Genetics & Development, 2024 - Elsevier
The aim of regenerative medicine is to restore specific functions to damaged cells or tissues.
A crucial aspect of success lies in effectively reintegrating these cells or tissues within the …
A crucial aspect of success lies in effectively reintegrating these cells or tissues within the …
Bending the Rules: Amplifying PD-L1 Immunoregulatory Function Through Flexible Polyethylene Glycol Synthetic Linkers
Immune checkpoint signaling, such as programmed cell death protein-1 (PD-1), is a key
target for immunotherapy due to its role in dampening immune responses. PD-1 signaling in …
target for immunotherapy due to its role in dampening immune responses. PD-1 signaling in …
Challenges and opportunities in the islet transplantation microenvironment: a comprehensive summary of inflammatory cytokine, immune cells, and vascular …
Q Chen, L Liu, X Zhao, J Liang, S Li - Frontiers in Immunology, 2023 - frontiersin.org
It is now understood that islet transplantation serves as a β-cell replacement therapy for type
1 diabetes. Many factors impact the survival of transplanted islets, especially those related to …
1 diabetes. Many factors impact the survival of transplanted islets, especially those related to …
Finishing the odyssey to a stem cell cure for type 1 diabetes
L Hunault, D Hesselson - npj Metabolic Health and Disease, 2024 - nature.com
For over two decades pluripotent stem cells have promised a renewable source of β cells to
treat patients with type 1 diabetes. Major efforts to optimize the differentiation, survival, and …
treat patients with type 1 diabetes. Major efforts to optimize the differentiation, survival, and …
Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation
S Grimus, V Sarangova, PB Welzel, B Ludwig… - Advanced … - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency primarily
due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM …
due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM …