Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Cancer is the world's major health issue, scavenging lives of millions throughout the world. A
number of anticancer drugs have figured prominently in the diagnosis and treatment of …

Adopting the molecular overlay approach, three novel sets of thiazepinopurines with
expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This …

Purine analogues were discovered to be inhibitors of CDK2, suggesting a potential
therapeutic scaffold. This paper addresses the design, synthesis, and anticancer evaluation …

The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH)
pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly …

Target identification is one of the most important bases for novel pesticide development;
pyruvate kinase (PK) was discovered as a potent fungicide target in our previous studies. To …

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and
FLT3-ITD as part of our program to develop 2, 6, 9-trisubstituted purine derivatives as …

Testing a number of N-[omega-(purin-6-yl) aminoalkanoyl] derivatives of 7, 8-difluoro-3, 4-
dihydro-3-methyl-2 H-[1, 4] benzoxazine in a panel of nine tumor cell lines has shown that …

Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the
development and progression of pancreatic cancer. For this reason, blockade of Hh pathway …

In this work, a series of 30 new 2, 6, 9-trisubstituted purine derivatives were synthesised and
evaluated in silico as potential ligands of the Smoothened (SMO) receptor, as well as their …