Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

In recent years, in-depth studies have shown that extracellular matrix stiffness plays an
important role in cell growth, proliferation, migration, immunity, malignant transformation …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

A recent US Food and Drug Administration report presented the currently available scientific
information related to biological response to metal implants. In this work, a multilevel …

As metastasis is responsible for most cancer-related deaths, understanding the cellular and
molecular events that lead to cancer cell migration and invasion will certainly provide …

Within the complex tumor microenvironment, cells experience mechanical cues—such as
extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, and fluid …

The tumor microenvironment is a key modulator in cancer progression and has become a
novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and …

Abstract Development of three dimensional (3D) in vitro models to realistically recapitulate
tumor microenvironment has the potential to improve translatability of anti-cancer drugs at …

Background Metastasis refers to the spread of cancer cells from a primary tumor to other
parts of the body via the lymphatic system and bloodstream. With tremendous effort over the …