Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review
JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …
[HTML][HTML] Recent updates on structural insights of MAO-B inhibitors: A review on target-based approach
Parkinson's disease is a neurodegenerative disorder characterized by slow movement,
tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's …
tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
[HTML][HTML] Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
The use of dual acetylcholinesterase (AChE)–monoamine oxidase B (MAO-B) inhibitors is a
new approach in the treatment of Alzheimer disease (AD). In this work, 14 new …
new approach in the treatment of Alzheimer disease (AD). In this work, 14 new …
Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors
To develop new acetylcholinesterase (AChE)–monoamine oxidase‐B (MAO‐B) dual
inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side …
inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side …
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
[HTML][HTML] Therapeutic potential of 1, 3, 4-oxadiazoles as potential lead compounds for the treatment of Alzheimer's disease
Monoamine oxidase and cholinesterase enzymes are important targets for the treatment of
several neurological diseases especially depression, Parkinson disease and Alzheimer's …
several neurological diseases especially depression, Parkinson disease and Alzheimer's …
“Urea to urea” approach: access to unsymmetrical ureas bearing pyridyl substituents
SO Kasatkina, KK Geyl, SV Baykov… - Advanced Synthesis …, 2022 - Wiley Online Library
A protocol for the synthesis of unsymmetrical ureas substituted by pyridyl/quinolinyl moiety
has been developed. This method concluded in metal‐and base‐free reamination of N, N …
has been developed. This method concluded in metal‐and base‐free reamination of N, N …
[HTML][HTML] Novel thiosemicarbazone derivatives: In vitro and in silico evaluation as potential MAO-B inhibitors
MAO-B inhibitors are frequently used in the treatment of neurodegenerative diseases such
as Parkinson's and Alzheimer's. Due to the limited number of compounds available in this …
as Parkinson's and Alzheimer's. Due to the limited number of compounds available in this …
Novel imidazole derivatives as potential aromatase and monoamine oxidase-B inhibitors against breast cancer
In this study, we developed a series of new aromatase MAO-B dual inhibitors against breast
cancer. Aromatase inhibitors are the most commonly used drugs clinically for breast cancer …
cancer. Aromatase inhibitors are the most commonly used drugs clinically for breast cancer …