Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

The Wnt (wingless-type) signaling pathway plays an important role in embryonic
development, tissue homeostasis, and tumor progression becaluse of its effect on cell …

Internationally adopted adolescents who are adopted as young children from conditions of
poverty and deprivation have poorer physical and mental health outcomes than do …

Most tumors initially respond to cytotoxic treatments, but acquired resistance often follows.
The tumor microenvironment (TME) is a major barrier to clinical success by compromising …

Metastatic or locally advanced prostate cancer (PCa) is typically treated with androgen
deprivation therapy (ADT). Initially, PCa responds to the treatment and regresses. However …

Increasing evidence has indicated that Wnt signaling plays complex roles in castration
resistant prostate cancer (CRPC). Although not all data were consistent, β-catenin nuclear …

Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate
cancer that can facilitate tumor formation, progression, and therapeutic resistance. Recent …

Abnormal methylation of secreted frizzled‑related proteins (SFRPs) has been observed in
various human cancer types. The loss of SFRP gene expression induces the activation of …

Osteosarcoma (OS), the most common primary bone tumor, is highly metastatic with high
chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells …