Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

The skeleton is one of the largest organs in the human body. In addition to its conventional
functions such as support, movement and protection, the skeleton also contributes to whole …

We recently showed that zoledronate prevented fractures in older women with osteopenia
(hip T‐scores between− 1.0 and− 2.5). In addition to fewer fractures, this study also …

Importance Previous studies have reported that drug treatments, particularly treatment with
bisphosphonates, is associated with reduced overall mortality rates in addition to decreased …

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative responses.
While vaccines form the frontline of defense, antiviral treatments such as nirmatrelvir have …

Background: Although there are several efficacious vaccines against COVID-19, vaccination
rates in many regions around the world remain insufficient to prevent continued high …

The prevalence of vitamin D deficiency in intensive care units ranges typically between 40
and 70%. There are many reasons for being or becoming deficient in the ICU. Hepatic …

Bisphosphonates are first line agents used to treat osteoporosis and reduce fracture rate.
They bind to areas of exposed calcium in the skeleton and cause osteoclast apoptosis …

Many critically ill patients are vitamin D and vitamin C deficient and the current international
guidelines state that hypovitaminoses should be compensated. However, uncertainty about …