Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …

Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery
systems, which have limitations for clinical applications. Translational efforts to develop …

Early diagnosis of acute liver failure (ALF) is critical for curable treatment of patients,
because most existing ALF therapies have narrow therapeutic time windows after disease …

Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

Drug-induced liver injury is an important clinical problem and a challenge for drug
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …

Acute liver failure can be the consequence of various etiologies, with most cases arising
from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Abstract Treatment of liver disease, caused by hepatotoxins, viral infections, alcohol
ingestion, or autoimmune conditions, remains challenging and costly. The liver has a …

Background & Aims Liver sinusoidal endothelial cell (LSEC) dysfunction has been reported
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …