Survivin, an inhibitor of apoptosis protein, is highly expressed in most cancers and
associated with chemotherapy resistance, increased tumor recurrence, and shorter patient …

Despite its genetic complexity and multifactoriality, two processes appear almost universally
compromised in cancer: the control of cell proliferation and the regulation of cell lifespan …

Background Colorectal cancer is thought to originate in the expansion of colonic crypt cells
as a result of aberrant gene expression caused by transcription factors of the T-cell factor …

Survivin, a novel member of inhibitor of apoptosis (IAP) protein family, is aberrantly
expressed in cancer but undetectable in normal, differentiated adult tissues. Current studies …

Apoptosis levels have been shown to predict tumor response to preoperative
radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a structurally …

It is well known that dysfunction of the apoptotic pathway confers apoptosis resistance and
results in a low sensitivity of human cancer cells to therapeutic agents. A novel strategy to …

The endocannabinoid system consists of an array of endogenously produced bioactive
lipids that activate cannabinoid receptors. Although the primary focus of endocannabinoid …

Survivin is a recently discovered protein belonging to the inhibitor of apoptosis (IAP) gene
family. IAP molecules are characterized by both the presence of a zinc-binding fold termed …

Survivin is an inhibitor of apoptosis protein, overexpressed in most human malignancies and
implicated in mitosis regulation and preservation of cell viability. In order to investigate the …

Survivin is unique for its expression in human malignancies but not in normal adult cells. It
has been implicated in sensitisation to chemotherapy and as a prognostic marker in several …