Paleoproteomics, the study of ancient proteins, is a rapidly growing field at the intersection of
molecular biology, paleontology, archaeology, paleoecology, and history. Paleoproteomics …

The reference human genome sequence is inarguably the most important and widely used
resource in the fields of human genetics and genomics. It has transformed the conduct of …

High-quality and complete reference genome assemblies are fundamental for the
application of genomics to biology, disease, and biodiversity conservation. However, such …

Whole-genome sequencing projects are increasingly populating the tree of life and
characterizing biodiversity,,–. Sparse taxon sampling has previously been proposed to …

Reconstruction of target genomes from sequence data produced by instruments that are
agnostic as to the species-of-origin may be confounded by contaminant DNA. Whether …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Long-range and highly accurate de novo assembly from short-read data is one of the most
pressing challenges in genomics. Recently, it has been shown that read pairs generated by …

Although many de novo genome assembly projects have recently been conducted using
high-throughput sequencers, assembling highly heterozygous diploid genomes is a …

Polymerase chain reaction (PCR) is a basic molecular biology technique with a multiplicity
of uses, including deoxyribonucleic acid cloning and sequencing, functional analysis of …