A comprehensive review on tyrosinase inhibitors
S Zolghadri, A Bahrami, MT Hassan Khan… - Journal of enzyme …, 2019 - Taylor & Francis
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …
Recent advances in the design and discovery of synthetic tyrosinase inhibitors
J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …
Targeting tyrosinase in hyperpigmentation: Current status, limitations and future promises
S Zolghadri, M Beygi, TF Mohammad… - Biochemical …, 2023 - Elsevier
Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …
Tyrosinase inhibitors naturally present in plants and synthetic modifications of these natural products as anti-melanogenic agents: a review
Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis.
In the current review, different chemical derivatives are explored which have been used as …
In the current review, different chemical derivatives are explored which have been used as …
Medicinal chemistry of oxazines as promising agents in drug discovery
Oxazines have brought much synthetic interest due to their extensive biological activities.
These are the important category of heterocycles, which may be formally derived from …
These are the important category of heterocycles, which may be formally derived from …
Heterocyclic compounds as synthetic tyrosinase inhibitors: recent advances
Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
Molecular docking, synthesis, and tyrosinase inhibition activity of acetophenone amide: Potential inhibitor of melanogenesis
Tyrosinase and its related proteins are responsible for pigmentation disorders, and inhibiting
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …
Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders
U Ghani - European Journal of Medicinal Chemistry, 2022 - Elsevier
Azoles are a famous and promising class of drugs for treatment of a range of ailments
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …
especially fungal infections. A wide variety of azole derivatives are also known to exhibit …
Hydroxyphenyl thiosemicarbazones as inhibitors of mushroom tyrosinase and antibrowning agents
M Carcelli, D Rogolino, J Bartoli, N Pala, C Compari… - Food chemistry, 2020 - Elsevier
Tyrosinase is a metalloenzyme involved in o-hydroxylation of monophenols and oxidation of
o-diphenols to o-quinones, with formation of brown or black pigments (melanines) …
o-diphenols to o-quinones, with formation of brown or black pigments (melanines) …
Biological and cheminformatics studies of newly designed triazole based derivatives as potent inhibitors against mushroom tyrosinase
A series of nine novel 1, 2, 4-triazole based compounds were synthesized through a
multistep reaction pathway and their structures were scrutinized by using spectral methods …
multistep reaction pathway and their structures were scrutinized by using spectral methods …