Role of natural products for the treatment of Alzheimer's disease
T Noori, AR Dehpour, A Sureda… - European journal of …, 2021 - Elsevier
Negative psychological and physiological consequences of neurodegenerative disorders
represent a high social and health cost. Among the neurodegenerative disorders …
represent a high social and health cost. Among the neurodegenerative disorders …
Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms
K Pagano, S Tomaselli, H Molinari… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
Anti-inflammatory, antioxidant, and neuroprotective effects of polyphenols—polyphenols as an element of diet therapy in depressive disorders
A Winiarska-Mieczan, M Kwiecień… - International Journal of …, 2023 - mdpi.com
Depressive disorders can affect up to 350 million people worldwide, and in developed
countries, the percentage of patients with depressive disorders may be as high as 10 …
countries, the percentage of patients with depressive disorders may be as high as 10 …
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
Y Xu, R Maya-Martinez, N Guthertz, GR Heath… - Nature …, 2022 - nature.com
Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in
pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to …
pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Anti-neuroinflammatory potential of natural products in the treatment of Alzheimer's disease
M Deng, W Yan, Z Gu, Y Li, L Chen, B He - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD) is an age-related chronic progressive neurodegenerative disease,
which is the main cause of dementia in the elderly. Much evidence shows that the onset and …
which is the main cause of dementia in the elderly. Much evidence shows that the onset and …
Myricetin inhibits α‐synuclein amyloid aggregation by delaying the liquid‐to‐solid phase transition
B Xu, X Mo, J Chen, H Yu, Y Liu - Chembiochem, 2022 - Wiley Online Library
The aggregation of α‐synuclein (α‐Syn) is a critical pathological hallmark of Parkinson's
disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD …
disease (PD). Prevention of α‐Syn aggregation has become a key strategy for treating PD …
Alzheimer's Disease Prevention through Natural Compounds: Cell-Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity
A Palmioli, V Mazzoni, A De Luigi… - ACS Chemical …, 2022 - ACS Publications
The relevant social and economic costs associated with aging and neurodegenerative
diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop …
diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop …
How oxidized EGCG remodels α-synuclein fibrils into non-toxic aggregates: insights from computational simulations
The misfolding and aggregation of the presynaptic protein α-synuclein (α-syn) is a
pathological hallmark of Parkinson's disease (PD). Targeting α-syn has emerged as a …
pathological hallmark of Parkinson's disease (PD). Targeting α-syn has emerged as a …
Cholinium-based ionic liquids attenuate the amyloid fibril formation of lysozyme: a greener concept of antiamyloidogenic ionic liquids
Amyloid fibrils share dominant β-sheet structures that form pathological deposits in human
organs causing various debilitating neurodegenerative diseases such as type II diabetes …
organs causing various debilitating neurodegenerative diseases such as type II diabetes …