Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …

Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain
trauma that uses a pneumatically or electromagnetically controlled piston to induce …

The purpose of this review is to survey the use of experimental animal models for studying
the chronic histopathological and behavioral consequences of traumatic brain injury (TBI) …

Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease constituting~
95% of late-onset non-familial/sporadic AD, and only~ 5% accounting for early-onset familial …

Traumatic brain injury (TBI) ranks as the leading cause of mortality and disability in the
young population worldwide. The annual US incidence of TBI in the general population is …

Object The favorable effect of statin treatment after traumatic brain injury (TBI) has been
shown in animal studies and is probably true in humans as well. The objective of this study …

Simvastatin, the fourth drug selected for testing by Operation Brain Trauma Therapy (OBTT),
is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor used clinically to reduce …

The clinical understanding of traumatic brain injury (TBI) and its manifestations is beginning
to change. Both clinicians and research scientists are recognizing that TBI and related …

Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of
neurological mortality and disability in the US However, therapeutic options are limited and …