The ability to fight bacterial infections with antibiotics has been a longstanding cornerstone
of modern medicine. However, wide-spread overuse and misuse of antibiotics has led to …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Infections caused by carbapenemase-producing enterobacteria (CPE) are a major concern
in clinical settings worldwide. Two fundamentally different processes shape the …

Infectious diseases caused by antibiotic-resistant bacterial (ARB) pathogens are a serious
threat to human and animal health. The active surveillance of ARB using an integrated one …

Although disinfection is key to infection control, the colonization patterns and resistomes of
hospital-environment microbes remain underexplored. We report the first extensive genomic …

Background Healthcare-associated infections due to antibiotic-resistant organisms pose an
acute and rising threat to critically ill and immunocompromised patients. To evaluate …

The hospital environment is a potential reservoir of bacteria with plasmids conferring
carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive …

Pseudomonas aeruginosa is a complex gram-negative facultative anaerobe replete with a
variety of arsenals to activate, modify, and destroy host defense mechanisms. The microbe is …

Abstract Carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii
(CRAB), and Pseudomonas aeruginosa (CRPsA) are a serious cause of healthcare …