Similar to functional magnetic resonance imaging (fMRI), functional near-infrared
spectroscopy (fNIRS) detects the changes of hemoglobin species inside the brain, but via …

The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …

Migraine is a complex neurovascular disease with a range of severity and symptoms, yet
mostly studied as one phenotype in genome-wide association studies (GWAS). Here we …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

Migraine is a common, disabling neurological disorder characterized by multiple phases:
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …