Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly aggressive
and hypoxic compared with other subtypes. The role of hypoxia inducible factor 1α (HIF-1α) …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Historically, natural plant-derived drugs received a great impact of consideration in the
treatment of several human-associated disorders. Cancer is a devastating disease and the …

Background Sanguinarine (SAN) is an important natural anti-inflammatory constitutes and
dietary supplementation with SAN could improve the relative length of the intestine, alter gut …

Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the
main groups of this class. These alkaloids include over 120 different compounds, mostly in …

For nearly eight millennia, opium poppy (Papaver somniferum) has been bred and cultivated
for therapeutic purposes. The medicinal properties of the plant are conferred by specialized …

The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as
ornamental plants. These plants are also valued in traditional medicine. Among all Papaver …

Oxeiptosis is a recently identified reactive oxygen species (ROS)-sensitive, caspase
independent, non-inflammatory regulated cell death pathway. The activation of Kelch-like …

Epidermal growth factor receptor (EGFR), also known as ErbB-1/HER-1, plays a key role in
the regulation of the cell proliferation, migration, differentiation, and survival. Since the …