The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

V Di Marzo - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-
arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 …

[HTML][HTML] Molecular alterations of the endocannabinoid system in psychiatric disorders

D Navarro, A Gasparyan, F Navarrete… - International journal of …, 2022 - mdpi.com
The therapeutic benefits of the current medications for patients with psychiatric disorders
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …

Rapid treatments for depression: endocannabinoid system as a therapeutic target

AM Sharafi, S Pakkhesal, A Fakhari… - Neuroscience & …, 2022 - Elsevier
Current first-line treatments for major depressive disorder (MDD), ie, antidepressant drugs
and psychotherapy, show delayed onset of therapeutic effect as late as 2–3 weeks or more …

[HTML][HTML] FAAH rs324420 Polymorphism: Biological Pathways, Impact on Elite Athletic Performance and Insights for Sport Medicine

HH Silva, V Tavares, BV Neto, F Cerqueira, R Medeiros… - Genes, 2023 - mdpi.com
Gene variation linked to physiological functions is recognised to affect elite athletic
performance by modulating training and competition-enabling behaviour. The fatty acid …

The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD

LH Anvar, A Alejafar, SE Moosavi, S Charsouei… - Epilepsy Research, 2023 - Elsevier
The endocannabinoid (eCB) system regulates many physiological functions in the central
nervous system. Fatty acid amide hydrolase (FAAH) is an essential enzyme in the eCB …

Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases

L Hosseinzadeh Anvar, A Ahmadalipour - BioFactors, 2023 - Wiley Online Library
The endocannabinoid (eCB) system is an important neuromodulatory system with its
extensive network of receptors throughout the human body that has complex actions in the …

Impacts of epidural electrical stimulation on Wnt signaling, FAAH, and BDNF following thoracic spinal cord injury in rat

M Ghorbani, P Shahabi, P Karimi… - Journal of Cellular …, 2020 - Wiley Online Library
Electrical stimulation (ES) has been shown to improve some of impairments after spinal cord
injury (SCI), but the underlying mechanisms remain unclear. The Wnt signaling pathways …

[HTML][HTML] Cannabinoids in the treatment of selected mental illnesses: Practical approach and overview of the literature

KR Müller-Vahl - Pharmacopsychiatry, 2024 - thieme-connect.com
Although an increasing number of patients suffering from mental illnesses self-medicate with
cannabis, current knowledge about the efficacy and safety of cannabis-based medicine in …

[HTML][HTML] Sphingolipid and endocannabinoid profiles in adult attention deficit hyperactivity disorder

N Brunkhorst-Kanaan, S Trautmann, Y Schreiber… - Biomedicines, 2021 - mdpi.com
Genes encoding endocannabinoid and sphingolipid metabolism pathways were suggested
to contribute to the genetic risk towards attention deficit hyperactivity disorder (ADHD). The …

[HTML][HTML] An Innovative Sandwich Type Biosensor towards Sensitive and Selective Monitoring of 2-Arachidonoylglycerol in Human Plasma Samples Using P(β-CD) …

N Aletaha, K Ghaseminasab, M Hasanzadeh… - Biosensors, 2022 - mdpi.com
In this work, 2-AG was successfully detected in human plasma samples using a new
sandwich-type electrochemical immune device based on poly-β-cyclodextrin P (β-CD) …