Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research and drug design
Peptide-based drug research has received high attention in the field of medicinal chemistry
over the past decade. For drug design, to improve proteolytic stability, it is desirable to …
over the past decade. For drug design, to improve proteolytic stability, it is desirable to …
Selective Synthesis of Fluorine‐Containing Cyclic β‐Amino Acid Scaffolds
Fluorine‐containing organic molecules have generated increasing impact in drug research
over the past decade. Their preparation and development of novel synthetic methods …
over the past decade. Their preparation and development of novel synthetic methods …
Recent progress in the selective fluorinations of some functionalized cycloalkenes
Organofluorine compounds have had an increasing impact in synthetic organic chemistry
and pharmaceutical research over the past two decades. Their syntheses and the …
and pharmaceutical research over the past two decades. Their syntheses and the …
A decade update on synthesis of bicyclic β-lactams and their transformation into synthetically/biologically relevant carbocyclic and heterocyclic moieties
J Bhalla - Tetrahedron, 2024 - Elsevier
Bicyclic β-lactams constitute an important class of fused-heterocyclic systems which have
remained as an effective fighting tool against wide range of bacterial infections throughout …
remained as an effective fighting tool against wide range of bacterial infections throughout …
A stereocontrolled protocol to highly functionalized fluorinated scaffolds through a fluoride opening of oxiranes
A novel selective and substrate-dependent synthetic protocol has been developed towards
the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives …
the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives …
Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides
Cyclic saturated aminosulfonyl fluorides were synthesized as their HCl salts. The
compounds were found to be stable upon storage and could be used for the protecting …
compounds were found to be stable upon storage and could be used for the protecting …
Synthesis of novel fluorinated building blocks via halofluorination and related reactions
A study exploring halofluorination and fluoroselenation of some cyclic olefins, such as
diesters, imides, and lactams with varied functionalization patterns and different structural …
diesters, imides, and lactams with varied functionalization patterns and different structural …
Structural Diversity‐Oriented Synthesis of Orthogonally Protected Cyclic Amino Acid Derivatives with Multiple Stereogenic Centers
The synthesis of three‐dimensional cyclopentane amino acid derivatives with multiple
stereocenters and with high regiochemical and diastereochemical diversity has been …
stereocenters and with high regiochemical and diastereochemical diversity has been …
Stereo-and regiocontrolled synthesis of highly functionalized cyclopentanes with multiple chiral centers
The synthesis of some highly substituted three-dimensional cyclopentanes with multiple
chiral centers and with high regiochemical and stereochemical diversity has been …
chiral centers and with high regiochemical and stereochemical diversity has been …
[PDF][PDF] Fluorination of some functionalized cycloalkenes through epoxidation and oxirane opening with Deoxofluor or XtalFluor-E
A convenient, simple synthetic method is described for the synthesis of some
fluorinecontaining, highly functionalized cycloalkane derivatives. The synthetic protocol …
fluorinecontaining, highly functionalized cycloalkane derivatives. The synthetic protocol …