Obesity, adipose tissue and vascular dysfunction

M Koenen, MA Hill, P Cohen, JR Sowers - Circulation research, 2021 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging

ACT Ng, V Delgado, BA Borlaug, JJ Bax - Nature Reviews Cardiology, 2021 - nature.com
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Local and systemic effects of the multifaceted epicardial adipose tissue depot

G Iacobellis - Nature Reviews Endocrinology, 2015 - nature.com
Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic
effects. This tissue is distinguished from other visceral fat depots by a number of anatomical …

Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions

CX Wong, AN Ganesan… - European heart …, 2017 - academic.oup.com
Obesity is increasingly recognized as a major modifiable determinant of atrial fibrillation
(AF). Although body mass index and other clinical measures are useful indications of …

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features

G Iacobellis, AC Bianco - Trends in Endocrinology & Metabolism, 2011 - cell.com
Epicardial adipose tissue is an unusual visceral fat depot with anatomical and functional
contiguity to the myocardium and coronary arteries. Under physiological conditions …

Echocardiographic epicardial fat: a review of research and clinical applications

G Iacobellis, HJ Willens - Journal of the American Society of …, 2009 - Elsevier
Epicardial fat plays a role in cardiovascular diseases. Because of its anatomic and functional
proximity to the myocardium and its intense metabolic activity, some interactions between …

Pericardial fat and the risk of heart failure

S Kenchaiah, J Ding, JJ Carr, MA Allison… - Journal of the American …, 2021 - jacc.org
Background Obesity is a well-established risk factor for heart failure (HF). However,
implications of pericardial fat on incident HF is unclear. Objectives This study sought to …

Characterization of the inflammatory‐metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution …

M Packer, CSP Lam, LH Lund… - European Journal of …, 2020 - Wiley Online Library
Accumulating evidence points to the existence of an inflammatory‐metabolic phenotype of
heart failure with a preserved ejection fraction (HFpEF), which is characterized by …

Pericardial fat is associated with atrial fibrillation severity and ablation outcome

CX Wong, HS Abed, P Molaee, AJ Nelson… - Journal of the American …, 2011 - jacc.org
Objectives: The aim of this study was to characterize the relationship between pericardial fat
and atrial fibrillation (AF). Background: Obesity is an important risk factor for AF. Pericardial …