emerging drug therapies in inflammatory bowel disease

LB Grossberg, K Papamichael… - Alimentary …, 2022 - Wiley Online Library
Background The landscape of inflammatory bowel disease (IBD) treatment is rapidly
expanding with the development of new therapeutic options. Aim To review the mechanisms …

Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments

P Wangchuk, K Yeshi, A Loukas - Trends in Pharmacological Sciences, 2024 - cell.com
Ulcerative colitis (UC) is one of the two forms of inflammatory bowel disease. It affects 5
million people globally, and is a chronic and recurring inflammation of the gastrointestinal …

Therapeutic targeting of intestinal fibrosis in Crohn's disease

G Santacroce, MV Lenti, A Di Sabatino - Cells, 2022 - mdpi.com
Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

How artificial intelligence will transform clinical care, research, and trials for inflammatory bowel disease

AL Silverman, D Shung, RW Stidham… - Clinical …, 2024 - Elsevier
Artificial intelligence (AI) refers to computer-based methodologies which use data to teach a
computer to solve pre-defined tasks; these methods can be applied to identify patterns in …

Role of TL1A in inflammatory autoimmune diseases: a comprehensive review

WD Xu, R Li, AF Huang - Frontiers in immunology, 2022 - frontiersin.org
TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in
different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune …

Emerging therapies for ulcerative colitis: updates from recent clinical trials

T AlAmeel, A AlMutairdi… - Clinical and Experimental …, 2023 - Taylor & Francis
Ulcerative colitis (UC) is a chronic and progressive inflammatory disorder that affects the
colon. The advent of advanced therapies such as biologic agents and small molecules has …

Inflammatory bowel disease: emerging therapies and future treatment strategies

E Bretto, DG Ribaldone, GP Caviglia, GM Saracco… - Biomedicines, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a term used to represent a group of chronic, relapsing
inflammatory disorders of the gastrointestinal tract. Crohn's disease (CD) and ulcerative …

Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort

RY Cordero, JB Cordero, AB Stiemke… - Human molecular …, 2023 - academic.oup.com
Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal disorder with
major phenotypes: ulcerative colitis (UC) and Crohn's disease (CD). Multiple studies have …

Tackling inflammatory bowel diseases: targeting proinflammatory cytokines and lymphocyte homing

Y Song, M Yuan, Y Xu, H Xu - Pharmaceuticals, 2022 - mdpi.com
Inflammatory bowel diseases (IBDs) are characterized by chronic inflammatory disorders
that are a result of an abnormal immune response mediated by a cytokine storm and …

Landscape of new drugs and targets in inflammatory bowel disease

S Vieujean, F D'Amico, P Netter… - United European …, 2022 - Wiley Online Library
Although the therapeutic armamentarium of Inflammatory bowel diseases (IBD) physicians
has expanded rapidly in recent years, a proportion of patients remain with a suboptimal …