Many proteins in living organisms are glycosylated. As their glycan patterns exhibit protein‐,
cell‐, and tissue‐specific heterogeneity, changes in the glycosylation levels could serve as …

The majority of cell differentiation associated tumor markers reported to date are either
glycoproteins or glycolipids. Despite there being a large number of glycoproteins reported …

Association of aberrant glycosylation with melanoma progression is based mainly on
analyses of cell lines. Here we present a systems-based study of glycomic changes and …

The introduction of unnatural chemical moieties into glycosaminoglycans (GAGs) has
enormous potential to facilitate studies of the mechanism and application of these critical …

The immunomodulatory family of Siglecs recognizes sialic acid-containing glycans as “self”,
which is exploited in cancer for immune evasion. The biochemical nature of Siglec ligands …

Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5
million cases of severe illness and∼ 290,000 to 645,000 deaths annually worldwide. The …

A key to improving vaccine design and vaccination strategy is to understand the mechanism
behind the variation of vaccine response with host factors. Glycosylation, a critical modulator …

We describe an approach to accelerate the search for competitive inhibitors for carbohydrate-
recognition domains (CRDs). Genetically encoded fragment-based discovery (GE-FBD) …

Cell surface glycans form a critical interface with the biological milieu, informing diverse
processes from the inflammatory cascade to cellular migration. Assembly of discrete …

Glycans are essential for the maintenance of normal biological function, with alterations in
glycan expression being a hallmark of cancer. Cancer stem cells (CSCs) are a subset of …