Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function
Multiple sclerosis is a major cause of neurological disability, which accrues predominantly
during progressive forms of the disease. Although development of multifocal inflammatory …
during progressive forms of the disease. Although development of multifocal inflammatory …
Cognitive impairment in multiple sclerosis
ND Chiaravalloti, J DeLuca - The Lancet Neurology, 2008 - thelancet.com
Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …
Alemtuzumab CARE-MS II 5-year follow-up: efficacy and safety findings
Objective: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active
relapsing-remitting multiple sclerosis and inadequate response to prior therapy. Methods: In …
relapsing-remitting multiple sclerosis and inadequate response to prior therapy. Methods: In …
Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study
AJC Eijlers, Q van Geest, I Dekker, MD Steenwijk… - Brain, 2018 - academic.oup.com
Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …
Despite the identification of cross-sectional MRI correlates of cognitive impairment …
Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
M Calabrese, F Agosta, F Rinaldi, I Mattisi… - Archives of …, 2009 - jamanetwork.com
Background Neuropsychological deficits in patients with multiple sclerosis (MS) have been
shown to be associated with the major pathological substrates of the disease, ie …
shown to be associated with the major pathological substrates of the disease, ie …
The clinico-radiological paradox in multiple sclerosis revisited
F Barkhof - Current opinion in neurology, 2002 - journals.lww.com
The use of magnetic resonance imaging as a surrogate outcome measure in clinical trials, or
even as a prognosticator in the assessment of the natural evolution, assumes a close …
even as a prognosticator in the assessment of the natural evolution, assumes a close …
Brain atrophy and lesion load predict long term disability in multiple sclerosis
Objective To determine whether brain atrophy and lesion volumes predict subsequent 10
year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic …
year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic …
Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options
A Andravizou, E Dardiotis, A Artemiadis… - Autoimmunity …, 2019 - Springer
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
characterized by focal or diffuse inflammation, demyelination, axonal loss and …
characterized by focal or diffuse inflammation, demyelination, axonal loss and …
Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated
syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the …
syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the …
The mechanism of action of interferon-β in relapsing multiple sclerosis
BC Kieseier - CNS drugs, 2011 - Springer
Multiple sclerosis (MS) is characterized by autoimmune inflammation and subsequent
neurodegeneration. It is believed that early in the disease course, proinflammatory T cells …
neurodegeneration. It is believed that early in the disease course, proinflammatory T cells …