Multiple sclerosis is a major cause of neurological disability, which accrues predominantly
during progressive forms of the disease. Although development of multifocal inflammatory …

Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …

Objective: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active
relapsing-remitting multiple sclerosis and inadequate response to prior therapy. Methods: In …

Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …

This book is the outcome of over 25 years of research into neurolinguistic aspects of
bilingualism. It will therefore draw extensively on scattered previously published material …

Background Neuropsychological deficits in patients with multiple sclerosis (MS) have been
shown to be associated with the major pathological substrates of the disease, ie …

Objective To determine whether brain atrophy and lesion volumes predict subsequent 10
year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic …

The use of magnetic resonance imaging as a surrogate outcome measure in clinical trials, or
even as a prognosticator in the assessment of the natural evolution, assumes a close …

Multiple sclerosis (MS) is characterized by autoimmune inflammation and subsequent
neurodegeneration. It is believed that early in the disease course, proinflammatory T cells …

In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated
syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the …