Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp.
pallidum. Clinical manifestations separate the disease into stages; late stages of disease are …

Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and
both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the …

New vaccine strategies are needed for prevention of leptospirosis, a widespread human and
veterinary disease caused by invasive spirochetes belonging to the genus Leptospira. We …

Anchoring of proteins to membranes by lipid modification is a universal strategy of both
prokaryotic and eukaryotic cells. The spirochaetes represent a distinct bacterial phylum that …

We report novel features of the genome sequence of Leptospira interrogans serovar
Copenhageni, a highly invasive spirochete. Leptospira species colonize a significant …

Pathogenic spirochetes are the causative agents of several important diseases including
syphilis, Lyme disease, leptospirosis, swine dysentery, periodontal disease and some forms …

Subunit vaccine discovery is an accepted clinical priority. The empirical approach is time-
and labor-consuming and can often end in failure. Rational information-driven approaches …

Syphilis is a prominent disease in low-and middle-income countries, and a re-emerging
public health threat in high-income countries. Syphilis elimination will require development …

Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum
subsp. pallidum. Despite inexpensive and effective antibiotic therapy, syphilis remains a …

The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that
have been linked to several patho/physiological functions, comprising bacterial …