Since the initial description of astrocytes by neuroanatomists of the nineteenth century, a
critical metabolic role for these cells has been suggested in the central nervous system …

We review current thinking about, and draw connections between, brain energetics and
metabolism, and between mitochondria and traumatic brain injury. Energy is fundamental to …

Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …

Quantitative systems pharmacology (QSP) modeling has become increasingly important in
pharmaceutical research and development, and is a powerful tool to gain mechanistic …

Background The energetics of cerebral activity critically relies on the functional and
metabolic interactions between neurons and astrocytes. Important open questions include …

Lactate in the brain is considered an important fuel and signalling molecule for neuronal
activity, especially during neuronal activation. Whether lactate is shuttled from astrocytes to …

This paper develops a three-dimensional spatially distributed model of brain cellular
metabolism and investigates how the locus of the synaptic activity in reference to the …

The human brain is a small organ which uses a disproportionate amount of the total
metabolic energy production in the body. While it is well understood that the most significant …

There is growing excitement around glial cells, as compelling evidence point to new,
previously unimaginable roles for these cells in information processing of the brain, with the …

The modeling of glutamate/GABA-glutamine cycling in the brain tissue involving astrocytes,
glutamatergic and GABAergic neurons leads to a complex compartmentalized metabolic …