Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

Despite the widely demonstrated public health benefits of contraception, limited
contraceptive options are available for men, placing both the contraceptive burden and …

We sequenced more than 52,500 single cells from embryonic day 11.5 (E11. 5)
postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial …

Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Spermatogenesis is a multi-step biological process where mitotically active diploid (2n)
spermatogonia differentiate into haploid (n) spermatozoa via regulated meiotic …

Spermatogenesis is a multi-step process of male germ cell (Gc) division and differentiation
which occurs in the seminiferous tubules of the testes under the regulation of gonadotropins …

Spermatogonial stem cells (SSCs) sustain spermatogenesis by balancing self-renewal and
initiation of differentiation to produce progenitor spermatogonia committed to forming sperm …

Spermatogenesis holds considerable promise for human-assisted reproduction and
livestock breeding based on stem cells. It occurs in seminiferous tubules within the testis …

Molecular studies of meiosis in mammals have been long relegated due to some intrinsic
obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to …