More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

Background Ferroptosis is a newly defined form of regulated cell death characterized by the
iron-dependent accumulation of lipid peroxidation and is involved in various …

During eukaryotic evolution, ribosomes have considerably increased in size, forming a
surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an …

Summary The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress
response, metabolic pathways, and innate immunity, and dysregulation of these processes …

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with
intracellular proteins through ufmylation, similar to ubiquitylation. Ufmylation is involved in …

Abstract p53 is the most intensively studied tumour suppressor. The regulation of p53
homeostasis is essential for its tumour-suppressive function,. Although p53 is regulated by …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Protein biogenesis at the endoplasmic reticulum (ER) in eukaryotic cells is monitored by a
protein quality control system named ER-associated protein degradation (ERAD). While …

Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …