Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …

Background: COVID-19 is a critical pandemic that has affected human communities
worldwide, and there is an urgent need to develop effective drugs. Although there are a …

Abstract Aurora Kinase A (AURKA) plays a central role as a serine/threonine kinase in
regulating cell cycle progression and mitotic functions. Over the years, extensive research …

We utilized a high-throughput cell-based assay to screen several chemical libraries for
inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora …

A critical part of the hepatitis B virus (HBV) life cycle is the packaging of the pregenomic RNA
(pgRNA) into nucleocapsids. While this process is known to involve several viral elements …

Chlamydia trachomatis is a clinically important bacterium that infects epithelial cells of the
genitourinary and respiratory tracts and the eye. These differentiated cells are in a quiescent …

Metabolic reprogramming is one of the crucial hallmarks of cancer. Hepatocellular
carcinoma (HCC) resulting from hepatitis B has various altered metabolic features. However …

Clear cell renal cell carcinoma (ccRCC) is regulated by methylation modifications and long
noncoding RNAs (lncRNAs). However, knowledge of N7-methylguanosine (m7G)-related …

Hepatitis B is caused by hepatitis B virus (HBV), and persistent HBV infection is a global
public health problem, with 257 million people as HBV chronic carriers. Viral covalently …

Aurora-A kinase is well known to regulate progression through mitosis. However, the kinase
also performs additional functions that could explain the failure of its inhibitors to be effective …