Epidrugs: targeting epigenetic marks in cancer treatment
CL Miranda Furtado, MC Dos Santos Luciano… - Epigenetics, 2019 - Taylor & Francis
Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …
[HTML][HTML] DNA methylation in human diseases
Z Jin, Y Liu - Genes & diseases, 2018 - Elsevier
Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …
development, an increasing amount of evidence has shown that it also plays an important …
Insulin receptor isoforms in physiology and disease: an updated view
A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
Epigenetics in cancer: fundamentals and beyond
S Biswas, CM Rao - Pharmacology & Therapeutics, 2017 - Elsevier
Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …
established as the fundamental mechanism leading towards carcinogenesis. Although this …
[HTML][HTML] Epigenetic and breast cancer therapy: promising diagnostic and therapeutic applications
The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes …
several factors such as late diagnosis, limited treatment options for certain BC subtypes …
Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease
Understanding the relative contributions of genetic and epigenetic abnormalities to acute
myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study …
myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study …
Melatonin and cancer suppression: insights into its effects on DNA methylation
Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated
biological effects include the regulation of circadian rhythms, which is important for optimal …
biological effects include the regulation of circadian rhythms, which is important for optimal …
Epigenetic aberrations in human pluripotent stem cells
S Bar, N Benvenisty - The EMBO journal, 2019 - embopress.org
Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in
investigating human development, and modeling and discovering therapies for a wide range …
investigating human development, and modeling and discovering therapies for a wide range …
Large-scale analysis of loss of imprinting in human pluripotent stem cells
S Bar, M Schachter, T Eldar-Geva, N Benvenisty - Cell reports, 2017 - cell.com
The parent-specific monoallelic expression of imprinted genes is controlled by DNA
methylation marks that are established differentially in the germline. Perturbation of these …
methylation marks that are established differentially in the germline. Perturbation of these …
The neglected insulin: IGF-II, a metabolic regulator with implications for diabetes, obesity, and cancer
When originally discovered, one of the initial observations was that, when all of the insulin
peptide was depleted from serum, the vast majority of the insulin activity remained and this …
peptide was depleted from serum, the vast majority of the insulin activity remained and this …