Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions

JL Huo, Q Feng, S Pan, WJ Fu, Z Liu, Z Liu - Cell death discovery, 2023 - nature.com
Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …

[HTML][HTML] Conceptual functional-by-design optimisation of the antioxidant capacity of trans-resveratrol, quercetin, and chlorogenic acid: application in a functional tea

H Corrigan, A Dunne, N Purcell, Y Guo, K Wang… - Food Chemistry, 2023 - Elsevier
Designing functional foods as delivery systems may become a tailored strategy to decrease
the risk of noncommunicable diseases. Therefore, this work aims to optimise a combination …

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

F Liu, L Zhao, T Wu, W Yu, J Li, W Wang… - Frontiers in …, 2024 - frontiersin.org
As the quality of life improves, the incidence of diabetes mellitus and its microvascular
complications (DMC) continues to increase, posing a threat to people's health and …

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

S Wu, D Lu, B Gajendran, Q Hu, J Zhang… - Phytotherapy …, 2023 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and
ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal …

Ferulic acid attenuates high glucose-induced MAM alterations via PACS2/IP3R2/FUNDC1/VDAC1 pathway activating proapoptotic proteins and ameliorates …

PS Raj, A Nair, MRP Rani, K Rajankutty… - International journal of …, 2023 - Elsevier
Background Diabetic cardiomyopathy (DCM) is one of the severe complications of diabetes
with no known biomarkers for early detection. Mitochondria-associated endoplasmic …

Unraveling the Phytochemical Profile Variability and Antioxidant Activities of Different Parts of Ammi visnaga (L) Collected from Taounate Region

ZE Jabboury, D Ousaaid, U Gašić, P Janaćković… - Chemistry Africa, 2024 - Springer
Ammi visnaga is a very popular medicinal plant well known for its biological properties
afforded by its dense chemical composition highly dependent on environmental factors. The …

Endoplasmic reticulum stress and quality control in relation to cisplatin resistance in tumor cells

W Mu, Y Zhi, J Zhou, C Wang, K Chai, Z Fan… - Frontiers in …, 2024 - frontiersin.org
The endoplasmic reticulum (ER) is a crucial organelle that orchestrates key cellular
functions like protein folding and lipid biosynthesis. However, it is highly sensitive to …

[HTML][HTML] Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT …

II Hegab, HE El-Horany, RN Abd-Ellatif… - International Journal of …, 2024 - mdpi.com
Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in
females of reproductive age, frequently associated with cardiac disturbances. This research …

D‐pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin‐mediated endoplasmic reticulum stress and glycophagy signaling pathway

X Li, X Yu, F Yu, C Fu, W Zhao, X Liu… - Phytotherapy …, 2024 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is an important complication resulting in heart failure and
death of diabetic patients. However, there is no effective drug for treatments. This study …

[HTML][HTML] Roles and mechanisms of natural drugs on sinus node dysfunction

M Chen, Q Wu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Sinus node dysfunction is a common arrhythmia disorder with a high incidence and
significant social and economic burden. Currently, there are no effective drugs for treating …