Biomedical applications of hydrogels in drug delivery system: An update

P Kesharwani, A Bisht, A Alexander, V Dave… - Journal of Drug Delivery …, 2021 - Elsevier
Conventional drug delivery system generally deals with the issues involving repeated
dosing and systemic toxicities. Since few decades, hydrogels have played a significant role …

Challenges and recent progress in oral drug delivery systems for biopharmaceuticals

B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

Alginate microparticles as oral colon drug delivery device: A review

L Agüero, D Zaldivar-Silva, L Peña, ML Dias - Carbohydrate polymers, 2017 - Elsevier
The increase in the research interest on alginate microparticles in pharmaceutical and
biomedical areas confirms its potential use as an effective matrix for drug and cell delivery …

Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers

LM Ensign, R Cone, J Hanes - Advanced drug delivery reviews, 2012 - Elsevier
Oral delivery is the most common method for drug administration. However, poor solubility,
stability, and bioavailability of many drugs make achieving therapeutic levels via the …

[HTML][HTML] Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Z Vinarov, B Abrahamsson, P Artursson… - Advanced Drug Delivery …, 2021 - Elsevier
Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts

E Moroz, S Matoori, JC Leroux - Advanced drug delivery reviews, 2016 - Elsevier
Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral
delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although …

SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs

Q Chen, F Zhang, L Dong, H Wu, J Xu, H Li, J Wang… - Cell research, 2021 - nature.com
Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene
expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 …

Therapeutic applications of hydrogels in oral drug delivery

LA Sharpe, AM Daily, SD Horava… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Oral delivery of therapeutics, particularly protein-based pharmaceutics, is of
great interest for safe and controlled drug delivery for patients. Hydrogels offer excellent …

Characterization and biological function of milk‐derived miRNAs

R Golan‐Gerstl, Y Elbaum Shiff… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope Breastfeeding is associated with reduced risk of infection, immune‐mediated
disorders, obesity, and even cancer. Recently it was found that breast milk contains a variety …

Life in 3D is never flat: 3D models to optimise drug delivery

KA Fitzgerald, M Malhotra, CM Curtin, FJ O'Brien… - Journal of controlled …, 2015 - Elsevier
The development of safe, effective and patient-acceptable drug products is an expensive
and lengthy process and the risk of failure at different stages of the development life-cycle is …