Physically cross-linked hydrogels are used as scaffolds in tissue engineering applications
because they are easily produced and avoid the potential toxicity produced by chemical …

There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Natural polymers, based on proteins or polysaccharides, have attracted increasing interest
in recent years due to their broad potential uses in biomedicine. The chemical stability …

Several collagen subtypes have been identified in hyaline articular cartilage. The main and
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …

Methotrexate (MTX), the gold standard against psoriasis, poses severe problems when
administered systemically viz increased toxicity, poor solubility and adverse reactions …

Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …

The repair and regeneration of articular cartilage represent important challenges for
orthopedic investigators and surgeons worldwide due to its avascular, aneural structure …

Mesenchymal stem cell derived extracellular matrix (MSC-ECM) is a natural biomaterial with
robust bioactivity and good biocompatibility, and has been studied as a scaffold for tissue …

The state-of-the-art approach to regenerating different tissues and organs is tissue
engineering which includes the three parts of stem cells (SCs), scaffolds, and growth factors …