The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Host innate recognition triggers key immune responses for viral elimination. The sensing
mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream …

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid
synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious …

ABSTRACT Nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) possesses
multiple and diverse functions in RNA replication, interferon resistance, and viral …

Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people
worldwide. Persistent virus infection often leads to cirrhosis and liver cancer. In the infected …

ABSTRACT BMS-790052 is the most potent hepatitis C virus (HCV) inhibitor reported to
date, with 50% effective concentrations (EC50s) of≤ 50 pM against genotype 1 replicons …

Genome replication is a crucial step in the life cycle of any virus. HCV is a positive strand
RNA virus and requires a set of nonstructural proteins (NS3, 4A, 4B, 5A, and 5B) as well as …

ABSTRACT A new protein expression vector design utilizing an N-terminal six-histidine tag
and tobacco etch virus protease cleavage site upstream of the hepatitis C virus NS5A …

Viruses are obligate intracellular parasites and therefore their replication completely
depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA …