The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

The smoothened (SMO) receptor, a key signal transducer in the hedgehog signalling
pathway, is responsible for the maintenance of normal embryonic development and is …

Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …

Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …