Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved
multi-subunit complexes that repress gene transcription by introducing trimethylation of …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

Polycomb complexes regulate cell type–specific gene expression programs through
heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is …

In mammalian cells genes that are in close proximity can be transcriptionally coupled:
silencing or activating one gene can affect its neighbors. Understanding these dynamics is …

Background Bromo-adjacent homology-plant homeodomain domain containing protein 1
(BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes …

The emergence of and transitions between distinct phenotypes in isogenic cells can be
attributed to the intricate interplay of epigenetic marks, external signals, and gene-regulatory …

Abstract Histone H2A monoubiquitination (H2Aub1) by the PRC1 subunit RING1B entails a
positive feedback loop, mediated by the RING1B-interacting protein RYBP. We uncover that …

In dogs, mammary cancer is the most common tumor type, especially in unspayed females.
As in humans, this type of cancer has spontaneous development and is influenced by …

Summary Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator that
trimethylates lysine 27 of histone 3 (H3K27me3) and is essential for embryonic development …

Histones are subjected to extensive covalent modifications that affect inter-nucleosomal
interactions as well as alter chromatin structure and DNA accessibility. Through switching …