Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

The vaccine weapon has resulted in being essential in fighting the COVID-19 outbreak, but it
is not fully preventing infection due to an alarming spreading of several identified variants of …

SARS-CoV-2 3CL protease (Main protease) and human cathepsin L are proteases that play
unique roles in the infection of human cells by SARS-CoV-2, the causative agent of COVID …

Breast cancer metastasis is associated with a poor prognosis and a high rate of mortality.
Cathepsin L (CTSL) is a lysosomal cysteine protease that promotes tumor metastasis by …

Chagas disease is caused by the eukaryote parasite Trypanosoma cruzi. Current treatment
exhibits limited efficacy and selenium-based compounds emerged as promising candidates …

Viral infections are one of the leading causes of acute morbidity in humans and much
endeavour has been made by the synthetic community for the development of drugs to treat …

Viral proteases are an important target for drug development, since they can modulate vital
pathways in viral replication, maturation, assembly and cell entry. With the (re) appearance …

Dysregulated human peptidases are implicated in a large variety of diseases such as
cancer, hypertension, and neurodegeneration. Viral proteases for their part are crucial for …

New affordable drugs are needed for the treatment of infection with the protozoan parasite
Trypanosoma cruzi responsible for the Chagas disease (CD). Only two old drugs are …

Heavy metal ions can disrupt biological functions via multiple molecular mechanisms,
including inhibition of enzymes. We investigate the interactions of human papain-like …