A convergence of cellular, genetic and biochemical studies supports the hypothesis that the
actin cytoskeleton is coupled to endocytic processes, but the roles played by actin filaments …

B lymphocytes are regarded as professional antigen-presenting cells (APCs) despite their
primary role in humoral immunity. Over the last two decades, studies designed to define the …

The chimeric anti-CD30 monoclonal antibody cAC10, linked to the antimitotic agents
monomethyl auristatin E (MMAE) or F (MMAF), produces potent and highly CD30-selective …

Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ultimately
leads to B cell activation. Using quantitative fluorescence resonance energy transfer …

Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of events
resulting in B cell activation. How the BCR becomes signaling-competent upon antigen …

Antigen binding to the B cell receptors (BCRs) induces BCR clustering, phosphorylation of
BCRs by the Src family kinase Lyn, initiation of signaling, and formation of an immune …

The high efficiency of Ag processing and presentation by B cells requires Ag-induced BCR
signaling and actin cytoskeleton reorganization, although the underlying mechanism for …

Induction of T cell antigen receptor (TCR) endocytosis has a significant impact on TCR
signaling and T cell behavior, but the molecular interactions coordinating internalization of …

Members of the Cbl family of molecular adaptors play key roles in regulating tyrosine kinase-
dependent signaling in a variety of cellular systems. Here we provide evidence that in B …

B cell antigen receptor (BCR) association with lipid rafts, the actin cytoskeleton, and clathrin-
coated pits influences B cell signaling and antigen presentation. Although all three cellular …