The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs),
which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor …

Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …

For over 100 years, thyroid hormones have been known to be essential for neonatal
neurodevelopment but whether they are required by the foetal brain remains a matter of …

Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2)
receptors. Here we describe a child with classic features of hypothyroidism (growth …

BACKGROUND: Six known steps are required for the circulating thyroid hormone (TH) to
exert its action on target tissues. For three of these steps, human mutations and distinct …

At least six major steps are required for secreted thyroid hormone (TH) to exert its action on
target tissues. Mutations interfering with three of these steps have been so far identified. The …

The genes encoding thyroid hormone receptor α and β (TRα and TRβ) encode four thyroid
hormone receptors and four variant isoforms with antagonistic properties. Because of this …

The transcriptional properties of unliganded thyroid hormone receptors are thought to cause
the misdevelopment during hypothyroidism of several functions essential for adult life. To …