Cancer biology as revealed by the research autopsy

CA Iacobuzio-Donahue, C Michael, P Baez… - Nature reviews …, 2019 - nature.com
A research autopsy is a post-mortem medical procedure performed on a deceased
individual with the primary goal of collecting tissue to support basic and translational …

[HTML][HTML] A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

SD Shemie, LC Wilson, L Hornby, J Basmaji… - Canadian Journal of …, 2023 - Springer
Abstract This 2023 Clinical Practice Guideline provides the biomedical definition of death
based on permanent cessation of brain function that applies to all persons, as well as …

[HTML][HTML] Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

B Domínguez-Gil, N Ascher, AM Capron… - Intensive care …, 2021 - Springer
A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

[HTML][HTML] Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: a United …

A Manara, SD Shemie, S Large, A Healey… - American Journal of …, 2020 - Elsevier
There is international variability in the determination of death. Death in donation after
circulatory death (DCD) can be defined by the permanent cessation of brain circulation. Post …

[HTML][HTML] Healthcare professionals' understandings of the definition and determination of death: a scoping review

K Zheng, S Sutherland, L Hornby, L Wilson… - Transplantation …, 2022 - journals.lww.com
Background. During the 1950s, advances in critical care, and organ transplantation altered
the relationship between organ failure and death. There has since been a shift away from …

Does controlled donation after circulatory death violate the dead donor rule?

EJ Nielsen Busch, MT Mjaaland - The American Journal of …, 2023 - Taylor & Francis
The vital status of patients who are a part of controlled donation after circulatory death
(cDCD) is widely debated in bioethical literature. Opponents to currently applied cDCD …

[HTML][HTML] Rationale for revisions to the definition of death and criteria for its determination in Canada

NB Murphy, M Hartwick, LC Wilson, C Simpson… - Canadian Journal of …, 2023 - Springer
Clarity regarding the biomedical definition of death and the criteria for its determination is
critical to inform practices in clinical care, medical research, law, and organ donation. While …

Controlled donation after circulatory determination of death: a scoping review of ethical issues, key concepts, and arguments

N Murphy, C Weijer, M Smith, J Chandler… - Journal of Law …, 2021 - cambridge.org
Controlled Donation After Circulatory Determination of Death: A Scoping Review of Ethical
Issues, Key Concepts, and Arguments Page 1 The Journal of Law, Medicine & Ethics, 49 (2021) …

[HTML][HTML] Advancing the scientific basis for determining death in controlled organ donation after circulatory determination of death

NB Murphy, SD Shemie, A Capron, RD Truog… - …, 2024 - journals.lww.com
In controlled organ donation after circulatory determination of death (cDCDD), accurate and
timely death determination is critical, yet knowledge gaps persist. Further research to …

Ensuring the permanent cessation of brain function during normothermic regional perfusion

M Slessarev, T Gofton, SD Shemie - Transplantation, 2022 - journals.lww.com
Normothermic regional perfusion (NRP) is an in situ perfusion technique that may improve
the quality and quantity of organs in donation after circulatory determination of death …