Virus-induced cell death has long been thought of as a double-edged sword in the inhibition
or exacerbation of viral infections. The vital role of iron, an essential element for various …

Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are
endemic to specific rodent hosts worldwide. Several arenaviruses cause severe …

Abstract Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon
binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria parasite exploit …

Porcine epidemic diarrhea virus (PEDV) mainly infects the intestinal epithelial cells of
newborn piglets causing acute, severe atrophic enteritis. The underlying mechanisms of …

Bolivian hemorrhagic fever (BHF) is a sporadic high-mortality febrile illness. Two etiological
agents are currently recognized: Machupo virus and Chapare virus. Infection in humans …

Mammarenaviruses are enveloped RNA viruses that can be associated with rodent-
transmitted diseases in humans. Their virions are composed of a nucleocapsid surrounded …

Abstract The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for
most higher organisms. It mediates cellular iron import through a constitutive clathrin …

Viral hemorrhagic fevers caused by emerging RNA viruses of the Arenavirus family are
among the most devastating human diseases. Climate change, global trade, and increasing …

Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for
severe cases of hemorrhagic fever. Virus entry is mediated by the glycoprotein complex …

Transferrin receptor 1 (TfR) delivers iron across cellular membranes by shuttling the ion
carrier protein transferrin. This ability to deliver large protein ligands inside cells is taken …