Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

Approximate 70% of cobra venom is composed of cytotoxin (CTX), which is responsible for
the dermonecrotic symptoms of cobra envenomation. However, CTX is generally low in …

Drugs modulate disease states through their actions on targets in the body. Determining
these targets aids the focused development of new treatments, and helps to better …

In this review, we present the latest advances in the field of multi-target-directed ligand
(MTDL) design for the treatment of various complex pathologies of multifactorial origin. In …

There is a growing interest to study and address neglected tropical diseases (NTD). To this
end, in silico methods can serve as the bridge that connects academy and industry …

Background We present a novel simulation method for generating connected differential
expression signatures. Traditional methods have struggled with the lack of reliable …

There is a pressing need to improve the efficiency of drug development, and nowhere is that
need more clear than in the case of neglected diseases like malaria. The peculiarities of …

Since its introduction about four decades ago, docking and scoring are now the very heart of
structure‐based drug design. The past 10–20 years have seen a plethora of docking and …